PROGRESSIVE FAILURE AFTER GASTRIC AND DUDEON RESECTION

National outcomes after gastric resection for neoplasm.

HYPOTHESIS That factors affecting outcomes of surgical resection in the treatment of gastric cancer can be identified using a large US database. DESIGN Retrospective observational study. SETTING The Nationwide Inpatient Sample from January 1, 1998, through December 31, 2003. PATIENTS We included 13 354 patient discharges (approximately 66 096 nationally by weighted analysis) who underwent...

MKK4 status predicts survival after resection of gastric adenocarcinoma.

HYPOTHESIS Lack of expression of the tumor-suppressor gene MKK4 is significantly correlated with poor survival after resection of gastric adenocarcinoma. DESIGN Retrospective review of medical records after construction and immunolabeling of tissue microarrays for clinical correlation. SETTING The Johns Hopkins Hospital, Baltimore, Md. PATIENTS Patients operated on because of gastric aden...

Gastric Cancer: the Importance of Pathology in Survival after Resection

Treatment Strategy after Incomplete Endoscopic Resection of Early Gastric Cancer

Endoscopic resection of early gastric cancer is defined as incomplete when tumor cells are found at the resection margin upon histopathological examination. However, a tumor-positive resection margin does not always indicate residual tumor; it can also be caused by tissue contraction during fixation, by the cautery effect during endoscopic resection, or by incorrect histopathological mapping. C...

Adjuvant S-1 chemotherapy after curative resection of gastric cancer.

To the Editor—In the February issue of Hong Kong Medical Journal, Yeo et al1 reported an informative study on the use of S-1 as adjunct chemotherapy after curative resection of gastric cancer. Since the active ingredient in S-1 is the prodrug tegafur, to be converted to 5-fluorouracil (5FU), much of the toxicity reduction depends on the degradation of 5FU by dihydropyrimidine dehydrogenase (DPD...